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Title 21

Displaying title 21, up to date as of 8/11/2026. Title 21 was last amended 8/06/2026.
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Title 21Food and DrugsPart / Section
Chapter IFood and Drug Administration, Department of Health and Human Services1 – 1299
Subchapter BFood for Human Consumption100 – 199
Part 170Food Additives170.3 – 170.285
Subpart EGenerally Recognized as Safe (GRAS) Notice170.203 – 170.285
§ 170.203Definitions.
§ 170.205Opportunity to submit a GRAS notice.
§ 170.210How to send your GRAS notice to FDA.
§ 170.215Incorporation into a GRAS notice.
§ 170.220General requirements applicable to a GRAS notice.
§ 170.225Part 1 of a GRAS notice: Signed statements and certification.
§ 170.230Part 2 of a GRAS notice: Identity, method of manufacture, specifications, and physical or technical effect.
§ 170.235Part 3 of a GRAS notice: Dietary exposure.
§ 170.240Part 4 of a GRAS notice: Self-limiting levels of use.
§ 170.245Part 5 of a GRAS notice: Experience based on common use in food before 1958.
§ 170.250Part 6 of a GRAS notice: Narrative.
§ 170.255Part 7 of a GRAS notice: List of supporting data and information in your GRAS notice.
§ 170.260Steps you may take before FDA responds to your GRAS notice.
§ 170.265What FDA will do with a GRAS notice.
§ 170.270Procedures that apply when the intended conditions of use of a notified substance include use in a product or products subject to regulation by the Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture.
§ 170.275Public disclosure of a GRAS notice.
§ 170.280Submission of a supplement.
§ 170.285Disposition of pending GRAS affirmation petitions.