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Title 21Chapter ISubchapter E → Part 556


Title 21: Food and Drugs


PART 556—TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD


Contents

Subpart A—General Provisions

§556.1   Scope.
§556.3   Definitions.
§556.5   General considerations.

Subpart B—Specific Tolerances for Residues of Approved and Conditionally Approved New Animal Drugs

§556.34   Albendazole.
§556.36   Altrenogest.
§556.38   Amoxicillin.
§556.40   Ampicillin.
§556.50   Amprolium.
§556.52   Apramycin.
§556.60   Avilamycin.
§556.68   Azaperone.
§556.70   Bacitracin.
§556.75   Bambermycins.
§556.100   Carbadox.
§556.110   Carbomycin.
§556.113   Ceftiofur.
§556.115   Cephapirin.
§556.118   Chloramine-T.
§556.120   Chlorhexidine.
§556.150   Chlortetracycline.
§556.160   Clopidol.
§556.163   Clorsulon.
§556.165   Cloxacillin.
§556.167   Colistimethate.
§556.168   Coumaphos.
§556.169   Danofloxacin.
§556.170   Decoquinate.
§556.180   Dichlorvos.
§556.185   Diclazuril.
§556.200   Dihydrostreptomycin.
§556.222   Doramectin.
§556.224   Efrotomycin.
§556.226   Enrofloxacin.
§556.227   Eprinomectin.
§556.230   Erythromycin.
§556.240   Estradiol and related esters.
§556.260   Ethopabate.
§556.273   Famphur.
§556.275   Fenbendazole.
§556.277   Fenprostalene.
§556.280   Fenthion.
§556.283   Florfenicol.
§556.286   Flunixin.
§556.292   Gamithromycin.
§556.300   Gentamicin.
§556.304   Gonadotropin.
§556.308   Halofuginone.
§556.310   Haloxon.
§556.316   Hetacillin.
§556.330   Hygromycin B.
§556.344   Ivermectin.
§556.346   Laidlomycin.
§556.347   Lasalocid.
§556.350   Levamisole.
§556.360   Lincomycin.
§556.370   Lubabegron.
§556.375   Maduramicin.
§556.380   Melengestrol.
§556.410   Metoserpate.
§556.420   Monensin.
§556.425   Morantel.
§556.426   Moxidectin.
§556.428   Narasin.
§556.430   Neomycin.
§556.445   Nicarbazin.
§556.460   Novobiocin.
§556.470   Nystatin.
§556.490   Ormetoprim.
§556.495   Oxfendazole.
§556.500   Oxytetracycline.
§556.510   Penicillin.
§556.513   Piperazine.
§556.515   Pirlimycin.
§556.517   Poloxalene.
§556.540   Progesterone.
§556.560   Pyrantel.
§556.570   Ractopamine.
§556.580   Robenidine.
§556.592   Salinomycin.
§556.597   Semduramicin.
§556.600   Spectinomycin.
§556.610   Streptomycin.
§556.620   Sulfabromomethazine.
§556.625   Sulfachloropyrazine.
§556.630   Sulfachlorpyridazine.
§556.640   Sulfadimethoxine.
§556.650   Sulfaethoxypyridazine.
§556.660   Sulfamerazine.
§556.670   Sulfamethazine.
§556.685   Sulfaquinoxaline.
§556.700   Sulfomyxin.
§556.710   Testosterone.
§556.720   Tetracycline.
§556.730   Thiabendazole.
§556.732   Tiamulin.
§556.733   Tildipirosin.
§556.735   Tilmicosin.
§556.739   Trenbolone.
§556.741   Tripelennamine.
§556.745   Tulathromycin.
§556.746   Tylosin.
§556.748   Tylvalosin.
§556.750   Virginiamycin.
§556.760   Zeranol.
§556.765   Zilpaterol.
§556.770   Zoalene.

Authority: 21 U.S.C. 342, 360b, 371.

Source: 84 FR 32993, July 11, 2019, unless otherwise noted.

Subpart A—General Provisions

§556.1   Scope.

(a) The Federal Food, Drug, and Cosmetic Act requires an applicant seeking approval or conditional approval of a new animal drug to submit a proposed tolerance as part of its new animal drug application when such a tolerance is needed to assure that the proposed use of the new animal drug will be safe (see sections 512(b)(1)(H) and 571(a)(2)(A) of the Federal Food, Drug, and Cosmetic Act). FDA assigns tolerances for animal drugs used in food-producing animals as part of the application approval process. Tolerances for approved and conditionally approved new animal drugs are codified in subpart B of this part.

(b) Compounds that have been found to be carcinogenic are regulated under subpart E of part 500 of this chapter.

§556.3   Definitions.

As used in this part:

Acceptable daily intake (ADI) means the daily intake which, during up to an entire life of a human, appears to be without adverse effects or harm to the health of the consumer. The ADI most often will be set on the basis of the drug's toxicological, microbiological, or pharmacological properties. It is usually expressed in micrograms or milligrams of the chemical per kilogram of body weight per day.

Acute reference dose (ARfD) means an estimate of the amount of residues expressed on a body weight basis that can be ingested in a period of 24 hours or less without adverse effects or harm to the health of the human consumer.

Edible tissues means muscle, liver, kidney, fat, skin with fat in natural proportions, whole eggs, whole milk, and honey.

Marker residue means the residue whose concentration is in a known relationship to the concentration of total residue in an edible tissue.

mg/kg means milligrams per kilogram.

Not required, in reference to tolerances in this part, means that at the time of approval:

(1) No withdrawal period was necessary for residues of the drug to deplete to or below the concentrations considered to be safe, or an adequate withdrawal period was inherent in the proposed drug use, and there was a rapid depletion of residues, so there was no concern about residues resulting from misuse or overdosing; or

(2) No withdrawal period was necessary because the drug was poorly absorbed or metabolized rapidly so as to make selection of an analyte impractical or impossible.

ppb means parts per billion (equivalent to nanograms per gram (ng/g) or µg/kg).

ppm means parts per million (equivalent to micrograms per gram (µg/g) or mg/kg).

ppt means parts per trillion (equivalent to picograms per gram (pg/g) or nanograms per kilogram (ng/kg)).

Residue means any compound present in edible tissues that results from the use of a drug, and includes the drug, its metabolites, and any other substance formed in or on food because of the drug's use.

Target tissue means the edible tissue selected to monitor for residues in the target animals.

Tolerance means the maximum concentration of a marker residue, or other residue indicated for monitoring, that can legally remain in a specific edible tissue of a treated animal.

Total residue means the aggregate of all compounds that results from the use of an animal drug, including the drug, its metabolites, and any other substances formed in or on food because of such drug use.

µg/kg means microgram per kilogram.

Zero, in reference to tolerances in this part, means any residues detected in the edible tissue renders it unsafe.

§556.5   General considerations.

(a) The tolerances listed in subpart B of this part pertain only to the species and production classes of the animal for which the drug use has been approved or conditionally approved. Approved and conditionally approved conditions of use in parts 516, 520, 522, 524, 526, 529, and 558 of this chapter, including the species and production classes of animals, are referenced in each tolerance section in subpart B of this part.

(b) All tolerances refer to the concentrations of a marker residue, or other residue indicated for monitoring, permitted in uncooked tissues.

(c) After a tolerance is listed, the finding that the concentration of the marker residue in the target tissue from a tested animal is at or below the tolerance indicates that all edible tissues (excluding milk and eggs unless otherwise indicated) from that tested animal are safe for human consumption. If a listed tolerance is not expressly linked to a target tissue, then the tolerance is specific only for the named edible tissue and inferences cannot be made about the safety of the other edible tissues from the tested animal.

(d) FDA requires that a drug sponsor submit a practicable method as part of their new animal drug application. FDA uses the practicable method to determine the quantity of the drug residues that can safely remain in edible tissues (i.e., the tolerance), the withdrawal period, and any other use restrictions necessary to ensure that the proposed use of the drug will be safe.

Subpart B—Specific Tolerances for Residues of Approved and Conditionally Approved New Animal Drugs

§556.34   Albendazole.

(a) Acceptable daily intake (ADI). The ADI for total residue of albendazole is 5 µg/kg of body weight per day.

(b) Tolerances. The tolerances for albendazole 2-aminosulfone (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 0.2 ppm.

(ii) Muscle: 0.05 ppm.

(2) Sheep. (i) Liver (target tissue): 0.25 ppm.

(ii) Muscle: 0.05 ppm.

(3) Goat. (i) Liver (target tissue): 0.25 ppm.

(ii) [Reserved]

(c) Related conditions of use. See §§520.38a and 520.38b of this chapter.

§556.36   Altrenogest.

(a) Acceptable daily intake (ADI). The ADI for total residue of altrenogest is 0.04 µg/kg of body weight per day.

(b) Tolerances. The tolerances for altrenogest (marker residue) are:

(1) Swine. (i) Liver (target tissue): 4 ppb.

(ii) Muscle: 1 ppb.

(2) [Reserved]

(c) Related conditions of use. See §520.48 of this chapter.

§556.38   Amoxicillin.

(a) [Reserved]

(b) Tolerances. The tolerance for amoxicillin is:

(1) Cattle. Edible tissues: 0.01 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.88d, 522.88, and 526.88 of this chapter.

§556.40   Ampicillin.

(a) [Reserved]

(b) Tolerances. The tolerances for ampicillin are:

(1) Cattle. Edible tissues: 0.01 ppm.

(2) Swine. Edible tissues: 0.01 ppm.

(c) Related conditions of use. See §§520.90e, 520.90f, 522.90a, and 522.90b of this chapter.

§556.50   Amprolium.

(a) [Reserved]

(b) Tolerances. The tolerances for amprolium are:

(1) Cattle. (i) Liver, kidney, and muscle: 0.5 ppm.

(ii) Fat: 2.0 ppm.

(2) Chickens and turkeys. (i) Liver and kidney: 1 ppm.

(ii) Muscle: 0.5 ppm.

(iii) Eggs:

(A) Egg yolks: 8 ppm.

(B) Whole eggs: 4 ppm.

(3) Pheasants. (i) Liver: 1 ppm.

(ii) Muscle: 0.5 ppm.

(c) Related conditions of use. See §§520.100, 558.55, and 558.58 of this chapter.

§556.52   Apramycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of apramycin is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerance for apramycin (marker residue) is:

(1) Swine. Kidney (target tissue): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.110 and 558.59 of this chapter.

§556.60   Avilamycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of avilamycin is 1.1 mg/kg of body weight per day.

(b) Tolerances. The tolerances for avilamycin are:

(1) Chickens. Edible tissues (excluding eggs): Not required.

(2) Swine. Edible tissues: Not required.

(c) Related conditions of use. See §558.68 of this chapter.

§556.68   Azaperone.

(a) Acceptable daily intake (ADI). The ADI for total residue of azaperone is 0.63 µg/kg of body weight per day.

(b) Tolerances. The tolerance for azaperone is:

(1) Swine. Edible tissues: Not required.

(2) [Reserved]

(c) Related conditions of use. See §522.150 of this chapter.

§556.70   Bacitracin.

(a) Acceptable daily intake (ADI). The ADI for total residue of bacitracin is 0.05 mg/kg of body weight per day.

(b) Tolerances. The tolerances for bacitracin are:

(1) Cattle. Edible tissues: 0.5 ppm.

(2) Chickens, turkeys, pheasants, quail. Edible tissues: 0.5 ppm.

(3) Swine. Edible tissues: 0.5 ppm.

(c) Related conditions of use. See §§520.154a, 520.154c, 558.76, and 558.78 of this chapter.

§556.75   Bambermycins.

(a) [Reserved]

(b) Tolerances. The tolerances for bambermycins are:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) Chickens and turkeys. Edible tissues (excluding eggs): Not required.

(3) Swine. Edible tissues: Not required.

(c) Related conditions of use. See §558.95 of this chapter.

§556.100   Carbadox.

(a) [Reserved]

(b) Tolerances. The tolerance for quinoxaline-2-carboxylic acid (marker residue) is:

(1) Swine. Liver (target tissue): 30 ppb.

(2) [Reserved]

(c) Related conditions of use. See §558.115 of this chapter.

§556.110   Carbomycin.

(a) [Reserved]

(b) Tolerances. The tolerance for carbomycin is:

(1) Chickens. Edible tissues (excluding eggs): Zero.

(2) [Reserved]

(c) Related conditions of use. See §520.1660a of this chapter.

§556.113   Ceftiofur.

(a) Acceptable daily intake and acute reference dose—(1) Acceptable daily intake (ADI). The ADI for total residue of ceftiofur is 30 µg/kg of body weight per day.

(2) Acute reference dose (ARfD). The ARfD for total residue of ceftiofur is 0.830 mg/kg of body weight.

(b) Tolerances. The tolerances for desfuroylceftiofur (marker residue) are:

(1) Cattle. (i) Kidney (target tissue): 0.4 ppm.

(ii) Liver: 2 ppm.

(iii) Muscle: 1 ppm.

(iv) Milk: 0.1 ppm.

(2) Chickens and turkeys. Edible tissues (excluding eggs): Not required.

(3) Goats. (i) Kidney (target tissue): 8 ppm.

(ii) Liver: 2 ppm.

(iii) Muscle: 1 ppm.

(iv) Milk: 0.1 ppm.

(4) Sheep. Edible tissues (excluding milk): Not required.

(5) Swine. (i) Kidney (target tissue): 0.25 ppm.

(ii) Liver: 3 ppm.

(iii) Muscle: 2 ppm.

(c) Related conditions of use. See §§522.313a, 522.313b, 522.313c, and 526.313 of this chapter.

§556.115   Cephapirin.

(a) [Reserved]

(b) Tolerances. The tolerances for cephapirin are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: 0.02 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§526.363 and 526.365 of this chapter.

§556.118   Chloramine-T.

(a) Acceptable daily intake (ADI). The ADI for total residue of chloramine-T is 5 µg/kg of body weight per day.

(b) Tolerances. The tolerance for para-toluenesulfonamide (marker residue) is:

(1) Fish. Muscle/skin (target tissue): 0.9 ppm.

(2) [Reserved]

(c) Related conditions of use. See §529.382 of this chapter.

§556.120   Chlorhexidine.

(a) [Reserved]

(b) Tolerances. The tolerance for chlorhexidine is:

(1) Cattle. Edible tissues (excluding milk): Zero.

(2) [Reserved]

(c) Related conditions of use. See §529.400 of this chapter.

§556.150   Chlortetracycline.

(a) Acceptable daily intake (ADI). The ADI for total residue of tetracyclines including chlortetracycline, oxytetracycline, and tetracycline is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for the sum of tetracycline residues are:

(1) Cattle. (i) Liver: 6 ppm.

(ii) Kidney and fat: 12 ppm.

(iii) Muscle: 2 ppm.

(2) Chickens, turkeys, and ducks. (i) Liver: 6 ppm.

(ii) Kidney and fat: 12 ppm.

(iii) Muscle: 2 ppm.

(iv) Eggs: 0.4 ppm for chlortetracycline only.

(3) Sheep. (i) Liver: 6 ppm.

(ii) Kidney and fat: 12 ppm.

(iii) Muscle: 2 ppm.

(4) Swine. (i) Liver: 6 ppm.

(ii) Kidney and fat: 12 ppm.

(iii) Muscle: 2 ppm.

(c) Related conditions of use. See §§520.441, 520.443, 520.445, 558.128, and 558.140 of this chapter.

§556.160   Clopidol.

(a) [Reserved]

(b) Tolerances. The tolerances for clopidol are:

(1) Chickens and turkeys. (i) Liver and kidney: 15 ppm.

(ii) Muscle: 5 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.175 of this chapter.

§556.163   Clorsulon.

(a) Acceptable daily intake (ADI). The ADI for total residue of clorsulon is 8 µg/kg of body weight per day.

(b) Tolerances. The tolerances for clorsulon (marker residue) are:

(1) Cattle. (i) Kidney (target tissue): 1.0 ppm.

(ii) Muscle: 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.462 and 522.1193 of this chapter.

§556.165   Cloxacillin.

(a) [Reserved]

(b) Tolerances. The tolerance for cloxacillin is:

(1) Cattle. Edible tissues: 0.01 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§526.464a, 526.464b, and 526.464c of this chapter.

§556.167   Colistimethate.

(a) [Reserved]

(b) Tolerances. The tolerance for colistimethate is:

(1) Chickens. Edible tissues (excluding eggs): Not required.

(2) [Reserved]

(c) Related conditions of use. See §522.468 of this chapter.

§556.168   Coumaphos.

(a) [Reserved]

(b) Tolerances. The tolerances for coumaphos (measured as coumaphos and its oxygen analog, O,O-diethyl O-3-chloro-4-methyl-2-oxo-2 H-1-benzopyran-7-yl phosphate) are:

(1) Cattle. (i) Edible tissues (excluding milk): 1 ppm.

(ii) Milk fat: 0.5 ppm.

(2) Chickens. (i) Edible tissues (excluding eggs): 1 ppm.

(ii) Eggs: 0.1 ppm.

(c) Related conditions of use. See §558.185 of this chapter.

§556.169   Danofloxacin.

(a) Acceptable daily intake (ADI). The ADI for total residue of danofloxacin is 2.4 µg/kg of body weight per day.

(b) Tolerances. The tolerances for danofloxacin (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 0.2 ppm.

(ii) Muscle: 0.2 ppm.

(2) [Reserved]

(c) Related conditions of use. See §522.522 of this chapter.

§556.170   Decoquinate.

(a) Acceptable daily intake (ADI). The ADI for total residue of decoquinate is 75 µg/kg of body weight per day.

(b) Tolerances. The tolerances for decoquinate are:

(1) Cattle. (i) Muscle: 1 ppm.

(ii) Other edible tissues (excluding milk): 2 ppm.

(2) Chickens. (i) Muscle: 1 ppm.

(ii) Other edible tissues (excluding eggs): 2 ppm.

(3) Goats. (i) Muscle: 1 ppm.

(ii) Other edible tissues (excluding milk): 2 ppm.

(c) Related conditions of use. See §§520.543 and 558.195 of this chapter.

§556.180   Dichlorvos.

(a) [Reserved]

(b) Tolerances. The tolerance for dichlorvos is:

(1) Swine. Edible tissues: 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.596 and 558.205 of this chapter.

§556.185   Diclazuril.

(a) Acceptable daily intake (ADI). The ADI for total residue of diclazuril is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for diclazuril are:

(1) Chickens and turkeys. (i) Liver: 3 ppm.

(ii) Muscle: 0.5 ppm.

(iii) Skin/fat: 1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.198 of this chapter.

§556.200   Dihydrostreptomycin.

(a) [Reserved]

(b) Tolerances. The tolerances for dihydrostreptomycin are:

(1) Cattle. (i) Kidney: 2.0 ppm.

(ii) Other edible tissues (excluding milk): 0.5 ppm.

(iii) Milk: 0.125 ppm.

(2) Swine. (i) Kidney: 2.0 ppm.

(ii) Other edible tissues: 0.5 ppm.

(c) Related conditions of use. See §§522.650, 526.1696b, and 526.1696c of this chapter.

§556.222   Doramectin.

(a) Acceptable daily intake (ADI). The ADI for total residue of doramectin is 0.75 µg/kg of body weight per day.

(b) Tolerances. The tolerances for doramectin (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 100 ppb.

(ii) Muscle: 30 ppb.

(2) Swine. Liver (target tissue): 160 ppb.

(c) Related conditions of use. See §§522.770 and 524.770 of this chapter.

§556.224   Efrotomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of efrotomycin is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerance for efrotomycin is:

(1) Swine. Edible tissues: Not required.

(2) [Reserved]

(c) Related conditions of use. See §558.235 of this chapter.

§556.226   Enrofloxacin.

(a) Acceptable daily intake (ADI). The ADI for total residue of enrofloxacin is 3 µg/kg of body weight per day.

(b) Tolerances. The tolerances for enrofloxacin are:

(1) Cattle. Liver (target tissue): 0.1 ppm desethylene ciprofloxacin (marker residue).

(2) Swine. Liver (target tissue): 0.5 ppm enrofloxacin (marker residue).

(c) Related conditions of use. See §522.812 of this chapter.

§556.227   Eprinomectin.

(a) Acceptable daily intake (ADI). The ADI for total residue of eprinomectin is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerances for eprinomectin B1a (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 1.5 ppm.

(ii) Muscle: 100 ppb.

(iii) Milk: 12 ppb.

(2) [Reserved]

(c) Related conditions of use. See §§522.814 and 524.814 of this chapter.

§556.230   Erythromycin.

(a) [Reserved]

(b) Tolerances. The tolerances for erythromycin are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: Zero.

(2) Chickens and turkeys. (i) Edible tissues (excluding eggs): 0.125 ppm.

(ii) Eggs: 0.025 ppm.

(3) Swine. Edible tissues: 0.1 ppm.

(c) Related conditions of use. See §§520.823, 522.820, 526.820, and 558.248 of this chapter.

§556.240   Estradiol and related esters.

(a) [Reserved]

(b) Residues. Residues of estradiol are not permitted in excess of the following increments above the concentrations of estradiol naturally present in untreated animals:

(1) Cattle. (i) Muscle: 120 ppt.

(ii) Fat: 480 ppt.

(iii) Kidney: 360 ppt.

(iv) Liver: 240 ppt.

(2) [Reserved]

(c) Related conditions of use. See §§522.840, 522.842, 522.850, 522.1940, 522.2477, and 522.2478 of this chapter.

§556.260   Ethopabate.

(a) [Reserved]

(b) Tolerances. The tolerances for ethopabate, measured as metaphenetidine, are:

(1) Chickens. (i) Liver: 1.5 ppm.

(ii) Kidney: 1.5 ppm.

(iii) Muscle: 0.5 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.58 of this chapter.

§556.273   Famphur.

(a) [Reserved]

(b) Tolerances. The tolerance for famphur including its oxygen analog is:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.1242g, 524.900, and 558.254 of this chapter.

§556.275   Fenbendazole.

(a) Acceptable daily intake (ADI). The ADI for total residue of fenbendazole is 40 µg/kg of body weight per day.

(b) Tolerances. The tolerances for fenbendazole are:

(1) Cattle. (i) Liver (target tissue): 0.8 ppm fenbendazole (marker residue).

(ii) Muscle: 0.4 ppm fenbendazole.

(iii) Milk: 0.6 ppm fenbendazole sulfoxide.

(2) Chickens. (i) Liver (target tissue): 5.2 ppm fenbendazole sulfone (marker residue).

(ii) Eggs: 1.8 ppm fenbendazole sulfone (marker residue).

(3) Goats. (i) Liver (target tissue): 0.8 ppm fenbendazole (marker residue).

(ii) Muscle: 0.4 ppm fenbendazole.

(4) Swine. (i) Liver (target tissue): 3.2 ppm fenbendazole (marker residue).

(ii) Muscle: 2 ppm fenbendazole.

(5) Turkeys. (i) Liver (target tissue): 6 ppm fenbendazole sulfone (marker residue).

(ii) Muscle: 2 ppm fenbendazole sulfone.

(c) Related conditions of use. See §§520.905a, 520.905c, 520.905d, 520.905e, and 558.258 of this chapter.

§556.277   Fenprostalene.

(a) Acceptable daily intake (ADI). The ADI for total residue of fenprostalene is 0.08 µg/kg of body weight per day.

(b) Tolerances. The tolerances for fenprostalene are:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) Swine. Edible tissues: Not required.

(c) Related conditions of use. See §522.914 of this chapter.

§556.280   Fenthion.

(a) [Reserved]

(b) Tolerances. The tolerance for fenthion is:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §524.920 of this chapter.

§556.283   Florfenicol.

(a) Acceptable daily intake (ADI). The ADI for total residue of florfenicol is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerances for florfenicol amine (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 3.7 ppm.

(ii) Muscle: 0.3 ppm.

(2) Swine. (i) Liver (target tissue): 2.5 ppm.

(ii) Muscle: 0.2 ppm.

(3) Catfish. Muscle (target tissue): 1 ppm.

(4) Freshwater-reared warmwater finfish (other than catfish) and salmonids. Muscle/skin (target tissue): 1 ppm.

(c) Related conditions of use. See §§520.955, 522.955, 522.956, and 558.261 of this chapter.

§556.286   Flunixin.

(a) Acceptable daily intake (ADI). The ADI for total residue of flunixin is 0.72 µg/kg of body weight per day.

(b) Tolerances. The tolerances for flunixin are:

(1) Cattle. (i) Liver (target tissue): 125 ppb flunixin free acid (marker residue).

(ii) Muscle: 25 ppb flunixin free acid.

(iii) Milk: 2 ppb 5-hydroxy flunixin (marker residue).

(2) Swine. (i) Liver (target tissue): 30 ppb flunixin free acid (marker residue).

(ii) Muscle: 25 ppb flunixin free acid.

(c) Related conditions of use. See §§522.956, 522.970, 522.1664, and 524.970 of this chapter.

§556.292   Gamithromycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of gamithromycin is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerances for gamithromycin (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 500 ppb.

(ii) Muscle: 150 ppb.

(2) [Reserved]

(c) Related conditions of use. See §522.1014 of this chapter.

§556.300   Gentamicin.

(a) Acceptable daily intake (ADI). The ADI for total residue of gentamicin is 60 µg/kg of body weight per day.

(b) Tolerances. The tolerances for gentamicin are:

(1) Chickens and turkeys. Edible tissues (excluding eggs): 0.1 ppm.

(2) Swine. (i) Liver: 0.3 ppm.

(ii) Kidney (target tissue): 0.4 ppm gentamicin (marker residue).

(iii) Fat: 0.4 ppm.

(iv) Muscle: 0.1 ppm.

(c) Related conditions of use. See §§522.1044a, 520.1044b, 520.1044c, and 524.1044e of this chapter.

§556.304   Gonadotropin.

(a) Acceptable daily intake (ADI). The ADI for residues of total gonadotropins (human chorionic gonadotropin and pregnant mare serum gonadotropin) is 42.25 International Units per kilogram of body weight per day.

(b) Tolerances. The tolerances for gonadotropin are:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) Fish. Edible tissues: Not required.

(3) Swine. Edible tissues: Not required.

(c) Related conditions of use. See §§522.1077, 522.1079, and 522.1081 of this chapter.

§556.308   Halofuginone.

(a) Acceptable daily intake (ADI). The ADI for total residue of halofuginone hydrobromide is 0.7 µg/kg of body weight per day.

(b) Tolerances. The tolerances for halofuginone (marker residue) are:

(1) Chickens. Liver (target tissue): 0.16 ppm.

(2) Turkeys. Liver (target tissue): 0.13 ppm.

(c) Related conditions of use. See §558.265 of this chapter.

§556.310   Haloxon.

(a) [Reserved]

(b) Tolerances. The tolerance for haloxon is:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.1120a and 520.1120b of this chapter.

§556.316   Hetacillin.

(a) [Reserved]

(b) Tolerances. The tolerances for ampicillin (marker residue for hetacillin) are:

(1) Cattle. Edible tissues: 0.01 ppm.

(2) [Reserved]

(c) Related conditions of use. See §526.1130 of this chapter.

[84 FR 53311, Oct. 7, 2019]

§556.330   Hygromycin B.

(a) [Reserved]

(b) Tolerances. The tolerances for hygromycin B are:

(1) Chickens. Edible tissues: Zero.

(2) Swine. Edible tissues: Zero.

(c) Related conditions of use. See §558.274 of this chapter.

§556.344   Ivermectin.

(a) Acceptable daily intake (ADI). The ADI for total residue of ivermectin is 1 µg/kg of body weight per day.

(b) Tolerances. The tolerances for 22,23-dihydroavermectin B1a (marker residue) are:

(1) American bison. Liver (target tissue): 15 ppb.

(2) Cattle. (i) Liver (target tissue): 100 ppb.

(ii) Muscle: 10 ppb.

(3) Reindeer. Liver (target tissue): 15 ppb.

(4) Sheep. Liver (target tissue): 30 ppb.

(5) Swine. (i) Liver (target tissue): 20 ppb.

(ii) Muscle: 20 ppb.

(c) Related conditions of use. See §§520.1192, 520.1195, 520.1197, 522.1192, 522.1193, 524.1193, and 558.300 of this chapter.

§556.346   Laidlomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of laidlomycin is 7.5 µg/kg of body weight per day.

(b) Tolerances. The tolerance for laidlomycin (marker residue) is:

(1) Cattle. Liver (target tissue): 0.2 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.305 of this chapter.

§556.347   Lasalocid.

(a) Acceptable daily intake (ADI). The ADI for total residue of lasalocid is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerances for lasalocid (marker residue) are:

(1) Cattle. Liver (target tissue): 0.7 ppm.

(2) Chickens. (i) Skin with adhering fat (target tissue): 1.2 ppm.

(ii) Liver: 0.4 ppm.

(3) Rabbits. Liver (target tissue): 0.7 ppm.

(4) Sheep. Liver (target tissue): 1.0 ppm.

(5) Turkeys. (i) Liver (target tissue): 0.4 ppm.

(ii) Skin with adhering fat: 0.4 ppm.

(c) Related conditions of use. See §558.311 of this chapter.

§556.350   Levamisole.

(a) [Reserved]

(b) Tolerances. The tolerances for levamisole are:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) Sheep. Edible tissues (excluding milk): 0.1 ppm.

(3) Swine. Edible tissues: 0.1 ppm.

(c) Related conditions of use. See §§520.1242a, 520.1242b, 520.1242d, 520.1242e, 520.1242f, 520.1242g, 522.1242, and 524.1240 of this chapter.

§556.360   Lincomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of lincomycin is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for lincomycin are:

(1) Chickens. Edible tissues (excluding eggs): Not required.

(2) Swine. (i) Liver: 0.6 ppm.

(ii) Muscle: 0.1 ppm.

(c) Related conditions of use. See §§520.1263c, 522.1260, and 558.325 of this chapter.

§556.370   Lubabegron.

(a) Acceptable daily intake (ADI). The ADI for total residues of lubabegron is 3 micrograms per kilogram of body weight per day.

(b) Tolerances. The tolerance for lubabegron (marker residue) is:

(1) Cattle. Liver (target tissue): 10 ppb.

(2) [Reserved]

(c) Related conditions of use. See §558.330 of this chapter.

§556.375   Maduramicin.

(a) [Reserved]

(b) Tolerances. The tolerance for maduramicin (marker residue) is:

(1) Chickens. Fat (target tissue): 0.38 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.340 of this chapter.

§556.380   Melengestrol.

(a) [Reserved]

(b) Tolerances. The tolerance for melengestrol is:

(1) Cattle. Fat: 25 ppb.

(2) [Reserved]

(c) Related conditions of use. See §558.342 of this chapter.

§556.410   Metoserpate.

(a) [Reserved]

(b) Tolerances. The tolerance for metoserpate is:

(1) Chickens. Edible tissues (excluding eggs): 0.02 ppm.

(2) [Reserved]

(c) Related conditions of use. See §520.1422 of this chapter.

§556.420   Monensin.

(a) Acceptable daily intake (ADI). The ADI for total residue of monensin is 12.5 µg/kg of body weight per day.

(b) Tolerances. The tolerances for monensin are:

(1) Cattle. (i) Liver: 0.10 ppm.

(ii) Muscle, kidney, and fat: 0.05 ppm.

(iii) Milk: Not required.

(2) Chickens and turkeys. Edible tissues (excluding eggs): Not required.

(3) Goats. Edible tissues (excluding milk): 0.05 ppm.

(4) Quail. Edible tissues (excluding eggs): Not required.

(c) Related conditions of use. See §558.355 of this chapter.

§556.425   Morantel.

(a) Acceptable daily intake (ADI). The ADI for total residue of morantel tartrate is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerances for N-methyl-1,3-propanediamine (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 0.7 ppm.

(ii) Milk: Not required.

(2) Goats. (i) Liver (target tissue): 0.7 ppm.

(ii) Milk: Not required.

(c) Related conditions of use. See §§520.1450a, 520.1450b, 520.1450c, and 558.360 of this chapter.

§556.426   Moxidectin.

(a) Acceptable daily intake (ADI). The ADI for total residue of moxidectin is 4 µg/kg of body weight per day.

(b) Tolerances. The tolerances for moxidectin (marker residue) are:

(1) Cattle. (i) Fat (target tissue): 900 ppb.

(ii) Liver: 200 ppb.

(iii) Muscle: 50 ppb.

(iv) Milk: 40 ppb.

(2) Sheep. (i) Fat (target tissue): 900 ppb.

(ii) Liver: 200 ppb.

(iii) Muscle: 50 ppb.

(c) Related conditions of use. See §§520.1454, 522.1450, and 524.1450 of this chapter.

§556.428   Narasin.

(a) Acceptable daily intake (ADI). The ADI for total residue of narasin is 5 µg/kg of body weight per day.

(b) Tolerances. The tolerance for narasin (marker residue) is:

(1) Chickens. Abdominal fat (target tissue): 480 ppb.

(2) [Reserved]

(c) Related conditions of use. See §§558.363 and 558.364 of this chapter.

§556.430   Neomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of neomycin is 6 µg/kg of body weight per day.

(b) Tolerances. The tolerances for neomycin are:

(1) Cattle. (i) Kidney (target tissue): 7.2 ppm.

(ii) Liver: 3.6 ppm.

(iii) Muscle: 1.2 ppm.

(iv) Fat: 7.2 ppm.

(v) Milk: 0.15 ppm.

(2) Sheep and goats. (i) Kidney (target tissue): 7.2 ppm.

(ii) Liver: 3.6 ppm.

(iii) Muscle: 1.2 ppm.

(iv) Fat: 7.2 ppm.

(v) Milk: 0.15 ppm.

(3) Swine. (i) Kidney (target tissue): 7.2 ppm.

(ii) Liver: 3.6 ppm.

(iii) Muscle: 1.2 ppm.

(iv) Fat: 7.2 ppm.

(4) Turkeys. (i) Skin with adhering fat: 7.2 ppm.

(ii) Liver: 3.6 ppm.

(iii) Muscle: 1.2 ppm.

(c) Related conditions of use. See §§520.1484, 524.1600b, 558.365, and 558.455 of this chapter.

§556.445   Nicarbazin.

(a) Acceptable daily intake (ADI). The ADI for total residues of nicarbazin (4,4-dinitrocarbanilide and 2-hydroxy-4,6-dimethylpyrimidine) is 200 µg/kg of body weight per day.

(b) Tolerances. The tolerance for 4,4-dinitrocarbanilide (marker residue) is:

(1) Chickens. Liver (target tissue): 52 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§558.364 and 558.366 of this chapter.

§556.460   Novobiocin.

(a) [Reserved]

(b) Tolerances. The tolerances for novobiocin are:

(1) Cattle. (i) Edible tissues (excluding milk): 1 ppm.

(ii) Milk: 0.1 ppm.

(2) Chickens, turkeys, and ducks. Edible tissues (excluding eggs): 1 ppm.

(c) Related conditions of use. See §§526.1590, 526.1696d, and 558.415 of this chapter.

§556.470   Nystatin.

(a) [Reserved]

(b) Tolerances. The tolerances for nystatin are:

(1) Cattle. Edible tissues (excluding milk): Zero.

(2) Chickens and turkeys. Edible tissues: Zero.

(c) Related conditions of use. See §§524.1600b and 558.430 of this chapter.

§556.490   Ormetoprim.

(a) [Reserved]

(b) Tolerances. The tolerances for ormetoprim are:

(1) Chickens, turkeys, ducks, and chukar partridges. Edible tissues (excluding eggs): 0.1 ppm.

(2) Salmonids and catfish. Edible tissues: 0.1 ppm.

(c) Related conditions of use. See §558.575 of this chapter.

§556.495   Oxfendazole.

(a) Acceptable daily intake (ADI). The ADI for total residue of oxfendazole is 7 µg/kg of body weight per day.

(b) Tolerances. The tolerance for fenbendazole (marker residue) is:

(1) Cattle. Liver (target tissue): 0.8 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.1629 and 520.1630 of this chapter.

§556.500   Oxytetracycline.

(a) Acceptable daily intake (ADI). The ADI for total tetracycline residues (chlortetracycline, oxytetracycline, and tetracycline) is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for the sum of tetracycline residues are:

(1) Cattle. (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(iv) Milk: 0.3 ppm.

(2) Chickens and turkeys. (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(3) Finfish. Muscle (with adhering skin when edible): 2 ppm.

(4) Lobster. Muscle: 2 ppm.

(5) Swine and sheep. (i) Muscle: 2 ppm.

(ii) Liver: 6 ppm.

(iii) Fat and kidney: 12 ppm.

(c) Related conditions of use. See §§520.1660a, 520.1660c, 520.1660d, 522.1660a, 522.1660b, 522.1662a, 522.1664, 529.1660, 558.450, and 558.455 of this chapter.

§556.510   Penicillin.

(a) [Reserved]

(b) Tolerances. The tolerances for penicillin are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.05 ppm.

(ii) Milk: Zero.

(2) Chickens. Edible tissues: Zero.

(3) Pheasants and quail. Edible tissues: Zero.

(4) Sheep and swine. Edible tissues: Zero.

(5) Turkeys. Edible tissues (excluding eggs): 0.01 ppm.

(c) Related conditions of use. See §§520.1696b, 522.1696a, 522.1696b, 526.1696a, 526.1696b, 526.1696c, and 526.1696d of this chapter.

§556.513   Piperazine.

(a) [Reserved]

(b) Tolerances. The tolerances for piperazine are:

(1) Chickens and turkeys. Edible tissues (excluding eggs): 0.1 ppm.

(2) Swine. Edible tissues: 0.1 ppm.

(c) Related conditions of use. See §520.1807 of this chapter.

§556.515   Pirlimycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of pirlimycin is 0.01 mg/kg of body weight per day.

(b) Tolerances. The tolerances for pirlimycin (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 0.5 ppm.

(ii) Muscle: 0.3 ppm.

(iii) Milk: 0.4 ppm.

(2) [Reserved]

(c) Related conditions of use. See §526.1810 of this chapter.

§556.517   Poloxalene.

(a) [Reserved]

(b) Tolerances. The tolerance for poloxalene is:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) [Reserved]

(c) Related conditions of use. See §§520.1840, 558.464, and 558.465 of this chapter.

§556.540   Progesterone.

(a) [Reserved]

(b) Residues. Residues of progesterone are not permitted in excess of the following increments above the concentrations of progesterone naturally present in untreated animals:

(1) Cattle and sheep. (i) Muscle: 5 ppb.

(ii) Liver: 15 ppb.

(iii) Kidney: 30 ppb.

(iv) Fat: 30 ppb.

(2) [Reserved]

(c) Related conditions of use. See §§522.1940 and 529.1940 of this chapter.

§556.560   Pyrantel.

(a) [Reserved]

(b) Tolerances. The tolerances for pyrantel are:

(1) Swine. (i) Liver and kidney: 10 ppm.

(ii) Muscle: 1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.2045 and 558.485 of this chapter.

§556.570   Ractopamine.

(a) Acceptable daily intake (ADI). The ADI for total residue of ractopamine hydrochloride is 1.25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for ractopamine (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 0.09 ppm.

(ii) Muscle: 0.03 ppm.

(2) Swine. (i) Liver (target tissue): 0.15 ppm.

(ii) Muscle: 0.05 ppm.

(3) Turkeys. (i) Liver (target tissue): 0.45 ppm.

(ii) Muscle: 0.1 ppm.

(c) Related conditions of use. See §558.500 of this chapter.

§556.580   Robenidine.

(a) [Reserved]

(b) Tolerances. The tolerances for robenidine are:

(1) Chickens. (i) Skin and fat: 0.2 ppm.

(ii) Other edible tissues (excluding eggs): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §558.515 of this chapter.

§556.592   Salinomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of salinomycin is 5 µg/kg of body weight per day.

(b) Tolerances. The tolerances for salinomycin are:

(1) Chickens. Edible tissues (excluding eggs): Not required.

(2) Quail. Edible tissues (excluding eggs): Not required.

(c) Related conditions of use. See §558.550 of this chapter.

§556.597   Semduramicin.

(a) Acceptable daily intake (ADI). The ADI for total residue of semduramicin is 3 µg/kg of body weight per day.

(b) Tolerances. The tolerances for semduramicin are:

(1) Chickens. (i) Liver: 400 ppb.

(ii) Muscle: 130 ppb.

(2) [Reserved]

(c) Related conditions of use. See §558.555 of this chapter.

§556.600   Spectinomycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of spectinomycin is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for spectinomycin are:

(1) Cattle. (i) Kidney (target tissue): 4 ppm spectinomycin (marker residue).

(ii) Muscle: 0.25 ppm.

(2) Chickens and turkeys. Edible tissues (excluding eggs): 0.1 ppm.

(3) Swine. Edible tissues: Not required.

(c) Related conditions of use. See §§520.1265, 520.2123b, 520.2123c, 522.2120, and 522.2121 of this chapter.

§556.610   Streptomycin.

(a) [Reserved]

(b) Tolerances. The tolerances for streptomycin are:

(1) Cattle and swine. (i) Kidney: 2.0 ppm.

(ii) Other edible tissues (excluding milk): 0.5 ppm.

(2) Chickens. (i) Kidney: 2.0 ppm.

(ii) Other edible tissues (excluding eggs): 0.5 ppm.

(c) Related conditions of use. See §520.2158 of this chapter.

§556.620   Sulfabromomethazine.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfabromomethazine are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: 0.01 ppm.

(2) [Reserved]

(c) Related conditions of use. See §520.2170 of this chapter.

§556.625   Sulfachloropyrazine.

(a) [Reserved]

(b) Tolerances. The tolerance for sulfachloropyrazine is:

(1) Chickens. Edible tissues (excluding eggs): Zero.

(2) [Reserved]

(c) Related conditions of use. See §520.2184 of this chapter.

§556.630   Sulfachlorpyridazine.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfachlorpyridazine are:

(1) Cattle and swine. Edible tissues (excluding milk): 0.1 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.2200 and 522.2200 of this chapter.

§556.640   Sulfadimethoxine.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfadimethoxine are:

(1) Catfish and salmonids. Edible tissues: 0.1 ppm.

(2) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: 0.01 ppm.

(3) Chickens, turkeys, ducks, and chukar partridges. Edible tissues (excluding eggs): 0.1 ppm.

(c) Related conditions of use. See §§520.2220a, 520.2220d, 520.2220e, 522.2220, and 558.575 of this chapter.

§556.650   Sulfaethoxypyridazine.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfaethoxypyridazine are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: Zero.

(2) Swine. Edible tissues: Zero.

(c) Related conditions of use. See §§520.2240a, 520.2240b, and 522.2240 of this chapter.

§556.660   Sulfamerazine.

(a) [Reserved]

(b) Tolerances. The tolerance for sulfamerazine is:

(1) Trout. Edible tissues: Zero.

(2) [Reserved]

(c) Related conditions of use. See §558.582 of this chapter.

§556.670   Sulfamethazine.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfamethazine are:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) Chickens and turkeys. Edible tissues (excluding eggs): 0.1 ppm.

(3) Swine. Edible tissues: 0.1 ppm.

(c) Related conditions of use. See §§520.2260a, 520.2260b, 520.2260c, 520.2261a, 520.2261b, 522.2260, 558.140, and 558.630 of this chapter.

§556.685   Sulfaquinoxaline.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfaquinoxaline are:

(1) Cattle. Edible tissues (excluding milk): 0.1 ppm.

(2) Chickens and turkeys. Edible tissues (excluding eggs): 0.1 ppm.

(c) Related conditions of use. See §§520.2325a, 520.2325b, and 558.586 of this chapter.

§556.700   Sulfomyxin.

(a) [Reserved]

(b) Tolerances. The tolerances for sulfomyxin are:

(1) Chickens and turkeys. Edible tissues (excluding eggs): Zero.

(2) [Reserved]

(c) Related conditions of use. See §522.2340 of this chapter.

§556.710   Testosterone.

(a) [Reserved]

(b) Residues. Residues of testosterone are not permitted in excess of the following increments above the concentrations of testosterone naturally present in untreated animals:

(1) Cattle. (i) Fat: 2.6 ppb.

(ii) Kidney: 1.9 ppb.

(iii) Liver: 1.3 ppb.

(iv) Muscle: 0.64 ppb.

(2) [Reserved]

(c) Related conditions of use. See §522.842 of this chapter.

§556.720   Tetracycline.

(a) Acceptable daily intake (ADI). The ADI for total tetracycline residues (chlortetracycline, oxytetracycline, and tetracycline) is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for the sum of tetracycline residues are:

(1) Cattle and sheep. (i) Kidney and fat: 12 ppm.

(ii) Liver: 6 ppm.

(iii) Muscle: 2 ppm.

(2) Chickens and turkeys. (i) Kidney and fat: 12 ppm.

(ii) Liver: 6 ppm.

(iii) Muscle: 2 ppm.

(3) Swine. (i) Kidney and fat: 12 ppm.

(ii) Liver: 6 ppm.

(iii) Muscle: 2 ppm.

(c) Related conditions of use. See §§520.2345c and 520.2345d of this chapter.

§556.730   Thiabendazole.

(a) [Reserved]

(b) Tolerances. The tolerances for thiabendazole are:

(1) Cattle. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: 0.05 ppm.

(2) Swine. Edible tissues: 0.1 ppm.

(3) Sheep and goats. (i) Edible tissues (excluding milk): 0.1 ppm.

(ii) Milk: 0.05 ppm.

(4) Pheasants. Edible tissues (excluding eggs): 0.1 ppm.

(c) Related conditions of use. See §§520.2380a, 520.2380b, 520.2380c, and 558.600 of this chapter.

§556.732   Tiamulin.

(a) Acceptable daily intake (ADI). The ADI for total residue of tiamulin is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerance for 8-alpha-hydroxymutilin (marker residue) is:

(1) Swine. Liver (target tissue): 0.6 ppm.

(2) [Reserved]

(c) Related conditions of use. See §§520.2455 and 558.612 of this chapter.

§556.733   Tildipirosin.

(a) Acceptable daily intake (ADI). The ADI for total residue of tildipirosin is 10 µg/kg of body weight per day.

(b) Tolerances. The tolerance for tildipirosin (the marker residue) is:

(1) Cattle. (i) Liver (the target tissue): 10 ppm.

(ii) [Reserved]

(2) [Reserved]

(c) Related conditions of use. See §522.2460 of this chapter.

§556.735   Tilmicosin.

(a) Acceptable daily intake (ADI). The ADI for total residue of tilmicosin is 25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for tilmicosin (marker residue) are:

(1) Cattle. (i) Liver (target tissue): 1.2 ppm.

(ii) Muscle: 0.1 ppm.

(2) Sheep. (i) Liver (target tissue): 1.2 ppm.

(ii) Muscle: 0.1 ppm.

(3) Swine. (i) Liver (target tissue): 7.5 ppm.

(ii) Muscle: 0.1 ppm.

(c) Related conditions of use. See §§520.2471, 522.2471, and 558.618 of this chapter.

§556.739   Trenbolone.

(a) Acceptable daily intake (ADI). The ADI for total residue of trenbolone is 0.4 µg/kg of body weight per day.

(b) Tolerances. The tolerance for trenbolone is:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) [Reserved]

(c) Related conditions of use. See §§522.2476, 522.2477, and 522.2478 of this chapter.

§556.741   Tripelennamine.

(a) [Reserved]

(b) Tolerances. The tolerances for tripelennamine are:

(1) Cattle. (i) Edible tissues (excluding milk): 200 ppb.

(ii) Milk: 20 ppb.

(2) [Reserved]

(c) Related conditions of use. See §522.2615 of this chapter.

§556.745   Tulathromycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of tulathromycin is 15 µg/kg of body weight per day.

(b) Tolerances. The tolerances for CP-60,300 (marker residue) are:

(1) Cattle. Liver (target tissue): 5.5 ppm.

(2) Swine. Kidney (target tissue): 15 ppm.

(c) Related conditions of use. See §522.2630 of this chapter.

§556.746   Tylosin.

(a) [Reserved]

(b) Tolerances. The tolerances for tylosin are:

(1) Cattle. (i) Liver, kidney, fat, and muscle: 0.2 ppm.

(ii) Milk: 0.05 ppm.

(2) Chickens and turkeys. (i) Liver, kidney, fat, and muscle: 0.2 ppm.

(ii) Eggs: 0.2 ppm.

(3) Swine. Liver, kidney, fat, and muscle: 0.2 ppm.

(c) Related conditions of use. See §§520.2640, 522.2640, 558.625, and 558.630 of this chapter.

§556.748   Tylvalosin.

(a) Acceptable daily intake (ADI). The ADI for total residues of tylvalosin is 47.7 µg/kg of body weight per day.

(b) Tolerances. A tolerance for tylvalosin in edible tissues of swine is not required.

(c) Related conditions of use. See §§520.2645 and 558.633 of this chapter.

§556.750   Virginiamycin.

(a) Acceptable daily intake (ADI). The ADI for total residue of virginiamycin is 250 µg/kg of body weight per day.

(b) Tolerances. The tolerances for virginiamycin are:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) Chickens. Edible tissues (excluding eggs): Not required.

(3) Swine. (i) Kidney, skin, and fat: 0.4 ppm.

(ii) Liver: 0.3 ppm.

(iii) Muscle: 0.1 ppm.

(4) Turkeys. Edible tissues (excluding eggs): Not required.

(c) Related conditions of use. See §558.635 of this chapter.

§556.760   Zeranol.

(a) Acceptable daily intake (ADI). The ADI for total residue of zeranol is 1.25 µg/kg of body weight per day.

(b) Tolerances. The tolerances for zeranol are:

(1) Cattle. Edible tissues (excluding milk): Not required.

(2) Sheep. Edible tissues (excluding milk): 20 ppb.

(c) Related conditions of use. See §522.2680 of this chapter.

§556.765   Zilpaterol.

(a) Acceptable daily intake (ADI). The ADI for total residue of zilpaterol is 0.083 µg/kg of body weight per day.

(b) Tolerances. The tolerance for zilpaterol freebase (marker residue) is:

(1) Cattle. Liver (target tissue): 12 ppb.

(2) [Reserved]

(c) Related conditions of use. See §558.665 of this chapter.

§556.770   Zoalene.

(a) [Reserved]

(b) Tolerances. The tolerances for zoalene and its metabolite 3-amino-5-nitro-o-toluamide are:

(1) Chickens. (i) Liver and kidney: 6 ppm.

(ii) Muscle: 3 ppm.

(iii) Fat: 2 ppm.

(2) Turkeys. Liver and muscle: 3 ppm.

(c) Related conditions of use. See §558.680 of this chapter.

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